Hydrochloric Acid → HCID 53641762, compound

Participants

Reaction Steps

A solution of ethyl 3-[3-allyl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2,3-dihydrobenzofuran-5-yl]acrylate (790 mg, 1.78 mmol) and sodium hydroxide (720 mg, 17.8 mmol) in THF (20 ml) is heated to reflux for 24 h. The mixture is treated with water and ethyl acetate, and acidified to pH 1 with a concentrated hydrochloric acid solution. After separation, the organic phase is washed twice with water, dried over magnesium sulphate, and concentrated in vacuo at 40° C. in a rotary evaporator. The solid obtained is washed with heptane.

Provenance & Evidence