反应详情

A mixture of 2-bromo-1-(tetrahydro-pyran-4-yl)-ethanone (0.6 g, 2.89 mmol) and 2-picoline (0.4 mL, 4.3 mmol) in methanol (10 mL) was heated to reflux and maintained overnight. The solvent was removed in vacuo to give a residue which was washed with 20% ethyl acetate in hexane to afford 2-methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide (0.75 g, 86%) as a semi-solid.

1. temperaturewas heated
2. temperatureto reflux
3. temperaturemaintained overnight
4. customThe solvent was removed in vacuo
5. customto give a residue which
6. washwas washed with 20% ethyl acetate in hexane