反应详情

0.5 g (0.0014 mol) of 4-amino-N-(2-bromo-6-methylamino-pyridin-4-yl)-benzenesulfonamide was dissolved in 25 ml of ethanol, treated with 0.05 g of Pd/C and hydrogenated with hydrogen gas under normal pressure for 1 hour. The catalyst was filtered off, the filtrate was concentrated and the residue was dissolved in 10 ml of 1N NaOH, filtered and the filtrate was then adjusted pH 8 by means of 1N HCl. The precipitate which separated slowly was filtered off under suction, rinsed and dried in a high vacuum. There was obtained 0.22 g (57%) of 4-amino-N-(2-methylamino-pyridin-4-yl)-benzenesulfonamide as white crystals; m.p.: >261° C. (dec).

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated
3. dissolutionthe residue was dissolved in 10 ml of 1N NaOH
4. filtrationfiltered
5. customThe precipitate which separated slowly
6. filtrationwas filtered off under suction
7. washrinsed
8. customdried in a high vacuum