HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-{[(Tert-butoxy)carbonyl](cyclopropyl)amino}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Glycine, N-cyclopropyl-, ethyl ester | HCID 22476174 | — |
| Product | 2-{[(Tert-butoxy)carbonyl](cyclopropyl)amino}acetic acid | HCID 22476118 | — |
Reaction Steps
Boc-N-Cyclopropylglycine was prepared from N-cyclopropylglycine ethyl ester, ethyl bromoacetate and cyclopropylamine (similar to J. W. Skiles et al., J. Med. Chem. 35 (1992) 641) and then converted under standard conditions into the Boc-protected form, then hydrolyzed with MeOH/2N NaOH and finally acidified with 1N HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06030972 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-8a5851f595b142bb9c5a1aa169a40697 |
| Source note | uspto-grants-2000_02 |