Ammonia → HCID 22476045, compound

Participants

Reaction Conditions

Reaction Steps

12.1 g (37.6 mmol) of 4-bromomethyl-3-iodobenzonitrile in 200 ml of MeOH/THF 1:1 were slowly added dropwise to 200 ml of conc. ammonia solution/MeOH (saturated with NH3) 1:1, simultaneously passing NH3 into the reaction mixture. The temperature was maintained at 50° C. After 4 h, the solvent was stripped off, and the product was taken up in DCM, dried and precipitated with ethereal HCl. 8.6 g of 4-aminomethyl-3-iodobenzonitrile hydrochloride were obtained. 1H-NMR (DMSO-d6, δ in ppm): 8.8 (broad signal, NH3+), 8.43 (1H), 7.98 (1H), 7.70 (1H), 4.13 (2H)

Provenance & Evidence