HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 4-(Bromomethyl)-2-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Methoxy-4-methylbenzonitrile | HCID 12495373 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 4-(Bromomethyl)-2-methoxybenzonitrile | HCID 21985007 | 35.3% |
Reaction Steps
4.6 g (31.3 mmol) of 4-methyl-2-methoxybenzonitrile were brominated with 34.7 mmol of N-bromosuccinimide in the presence of catalytic amounts of azobisisobutyronitrile in 60 ml of 1,2-dichloroethane under reflux. 2.5 g of the product were obtained. 1H-NMR (DMSO-d6, δ in ppm): 7.75 (d, 1H), 7.35 (s, broad, 1H), 7.15 (d, broad, 1H), 4.73 (s, 2H), 3.95 (s, 3H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06030972 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-cb015b0a30b246fa99e426201e5d5552 |
| Source note | uspto-grants-2000_02 |