HCID 12073752, compound → HCID 10432263, compound

HRID 378356Notes

Reaction equation

HRID 378356 reaction equation
[CH3:1][O:2][C:3]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:4]([O:15][C:16]1[N:21]=[C:20]([O:22][CH3:23])[C:19]2[CH2:24][CH2:25][CH2:26][C:18]=2[N:17]=1)[C:5]([O:7]CC1C=CC=CC=1)=[O:6].[H][H]>C(OCC)(=O)C.CO.[Pd]>[CH3:1][O:2][C:3]([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH:4]([O:15][C:16]1[N:21]=[C:20]([O:22][CH3:23])[C:19]2[CH2:24][CH2:25][CH2:26][C:18]=2[N:17]=1)[C:5]([OH:7])=[O:6]

Participants

5

Reactant 2

HCID 12073752HCID 12073752, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 10432263HCID 10432263, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

40 g (78.4 mmol) of benzyl 3-methoxy-2-(4-methoxy-6,7-dihydro-5H-cyclopentapyrimidin-2-yloxy)-3,3-diphenylpropionate were dissolved in 400 ml of ethyl acetate/methanol (4:1), about 500 mg of palladium on active carbon (10%) were added, and the mixture was exposed to a hydrogen atmosphere until no further gas was taken up. The catalyst was filtered off, the solution was evaporated, and the residue was crystallized from ether.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solution was evaporated
  3. customthe residue was crystallized from ether

Sources & evidence

ORD record
ord-ee645729cf5041298f73b0a2668c844c
Source dataset
uspto-grants-2000_02
Patent number
US06030975

Reaction notes

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