4-Chloro-2-(methylsulfanyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine → HCID 19353471, compound

HRID 378358Notes

Reaction equation

HRID 378358 reaction equation
Cl[C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[N:5]=[C:4]([S:11][CH3:12])[N:3]=1

Participants

4

Reactant 2

HCID 2316404-Chloro-2-(methylsulfanyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 19353471HCID 19353471, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

18.05 g (90 mmol) of 4-chloro-2-methylthio-6,7-dihydro-5H-cyclopentapyrimidine were dissolved in 200 ml of methanol. At 45° C., 16.7 g of sodium methoxide (as 30% strength solution in methanol) were added dropwise, and the mixture was stirred for 2 hours. The solution was evaporated, taken up in ethyl acetate and acidified with dilute hydrochloric acid, and the ethyl acetate extract was evaporated. 15.5 g of an oil remained.

Workup

  1. customThe solution was evaporated
  2. extractionthe ethyl acetate extract
  3. customwas evaporated

Sources & evidence

ORD record
ord-9f2ac25c85714b0faef68271e167ebf4
Source dataset
uspto-grants-2000_02
Patent number
US06030975

Reaction notes

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