2,5-Dimethoxybenzenesulfonyl chloride → HCID 15453193, compound

HRID 378429Notes

Reaction equation

HRID 378429 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[S:19](Cl)(=[O:21])=[O:20]>>[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[S:19]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:20])=[O:21]

Participants

3

Reactant 2

HCID 1370252,5-Dimethoxybenzenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 15453193HCID 15453193, compoundYield 58%

Procedure

2,5-Dimethoxy-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,5-dimethoxybenzenesulfonyl chloride according to the procedures described in Example 8 (see, also Example 30), below. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 118-120°, yield 58%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 118-120°, yield 58%

Sources & evidence

ORD record
ord-9fa4ad5288c448b4b3f87629c5b2eb08
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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