2-Methoxyphenylboronic acid → N-(3-methyl-5-isoxazolyl)-4-(2-methoxyphenyl)benzenesulfonamide

HRID 378445Notes

Reaction equation

HRID 378445 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14](Br)=[CH:13][CH:12]=2)(=[O:10])=[O:9])[O:4][N:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1B(O)O>>[CH3:1][C:2]1[CH:6]=[C:5]([NH:7][S:8]([C:11]2[CH:16]=[CH:15][C:14]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[O:19][CH3:18])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 15453181N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide

Product 1

HCID 15453195N-(3-methyl-5-isoxazolyl)-4-(2-methoxyphenyl)benzenesulfonamideYield 81%

Procedure

N-(3-methyl-5-isoxazolyl)-4-(2-methoxyphenyl)benzenesulfonamide was prepared in the same manner as described in Example 14 using N-(3-methyl-5-isoxazolyl)-4-bromobenzenesulfonamide and 2-methoxybenzeneboronic acid resulting in an 81% yield of the final product.

Workup

  1. customN-(3-methyl-5-isoxazolyl)-4-(2-methoxyphenyl)benzenesulfonamide was prepared in the same manner

Sources & evidence

ORD record
ord-d48ed3fadcac4b24b3ec683e1d7ff9a7
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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