3-Nitrobenzenesulfonyl chloride → HCID 18617395, compound

HRID 378460Notes

Reaction equation

HRID 378460 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[N+:9]([C:12]1[CH:13]=[C:14]([S:18](Cl)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1)([O-:11])=[O:10]>>[N+:9]([C:12]1[CH:13]=[C:14]([S:18]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1)([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 84763-Nitrobenzenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617395HCID 18617395, compoundYield 55%

Procedure

3-Nitro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared in the same manner as described in Example 30 from 5-amino-4-bromo-3-methylisoxazole and 3-nitrobenzenesulfonyl chloride in 55% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 151-153° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 151-153° C.

Sources & evidence

ORD record
ord-ef36e30553ef4b88b37fbfc479ab44c9
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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