o-Toluenesulfonyl chloride → HCID 18617327, compound

HRID 378470Notes

Reaction equation

HRID 378470 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[C:9]1([CH3:19])[C:10]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:12]=[CH:13][CH:14]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:15]([C:10]1[C:9]([CH3:19])=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 8623o-Toluenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617327HCID 18617327, compoundYield 88%

Procedure

N-(4-Bromo-3-methyl-5-isoxazolyl)-2-toluenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2-toluenesulfonyl chloride according to the procedures described in Example 25b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give white crystalline solid, m.p. 93-96° C., yield 88%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give white crystalline solid, m.p. 93-96° C., yield 88%

Sources & evidence

ORD record
ord-f1d4384f80fc41ce87004c35f323e412
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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