3-Fluorobenzenesulfonyl Chloride → HCID 18617326, compound

HRID 378472Notes

Reaction equation

HRID 378472 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[F:9][C:10]1[CH:11]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1>>[F:9][C:10]1[CH:11]=[C:12]([S:16]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617326HCID 18617326, compoundYield 88%

Procedure

3-Fluoro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 3-fluorobenzenesulfonyl chloride according to the procedures described in Example 25b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a light yellow solid, m.p. 125-128° C., yield 88%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a light yellow solid, m.p. 125-128° C., yield 88%

Sources & evidence

ORD record
ord-aa016ec712064018a4df3726fe37f29e
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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