3-Methylbenzenesulphonyl chloride → HCID 18617303, compound

HRID 378478Notes

Reaction equation

HRID 378478 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[C:9]1([CH3:19])[CH:14]=[CH:13][CH:12]=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:10]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:15]([C:11]1[CH:10]=[C:9]([CH3:19])[CH:14]=[CH:13][CH:12]=1)(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 27345953-Methylbenzenesulphonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617303HCID 18617303, compoundYield 63%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-3-toluenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 3-toluenesulfonyl chloride according to the procedures described in Example 30. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 138-140° C., yield 63%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 138-140° C., yield 63%

Sources & evidence

ORD record
ord-b3deea8c38b148cc90336cd143126939
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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