Benzenesulfonyl chloride, 3,4-dichloro- → HCID 18617354, compound

HRID 378486Notes

Reaction equation

HRID 378486 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[CH:11]=[C:12]([S:17](Cl)(=[O:19])=[O:18])[CH:13]=[CH:14][C:15]=1[Cl:16]>>[Cl:9][C:10]1[CH:11]=[C:12]([S:17]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:18])=[O:19])[CH:13]=[CH:14][C:15]=1[Cl:16]

Participants

3

Reactant 2

HCID 7383Benzenesulfonyl chloride, 3,4-dichloro-HCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617354HCID 18617354, compoundYield 60%

Procedure

3,4-Dichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 3,4-dichlorobenzenesulfonyl chloride according to the procedures described in Example 30. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 144-146° C., yield 60%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 144-146° C., yield 60%

Sources & evidence

ORD record
ord-04efb03fef294a0bab0a2f7198f78a0e
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

Loading…