3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 15453212, compound

HRID 378490Notes

Reaction equation

HRID 378490 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[F:9][C:10]([F:22])([F:21])[C:11]1[CH:12]=[C:13]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1>>[F:22][C:10]([F:9])([F:21])[C:11]1[CH:12]=[C:13]([S:17]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:18])=[O:19])[CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 15453212HCID 15453212, compoundYield 83%

Procedure

3-Trifluoromethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 3-trifluoromethylbenzenesulfonyl chloride according to the procedures described in Example 30. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 113-115° C., yield 83%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 113-115° C., yield 83%

Sources & evidence

ORD record
ord-7208903e1b6d452bac625a0602fbf419
Source dataset
uspto-grants-2000_02
Patent number
US06030991

Reaction notes

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