1-Phenyl-piperidin-4-one oxime → 1-Phenylpiperidin-4-amine

HRID 37850Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 37850
[C:1]1([N:7]2[CH2:12][CH2:11][C:10](=[N:13]O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Ni]>[C:1]1([N:7]2[CH2:8][CH2:9][CH:10]([NH2:13])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 3438331-Phenyl-piperidin-4-one oxime

Produkt 1

HCID 211933471-Phenylpiperidin-4-amineAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-phenyl-piperidin-4-one oxime (0.18 g, 0.95 mmol) in methanol (10 mL) was hydrogenated over Raney nickel (0.15 g) under balloon pressure at ambient temperature for 6 h. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo. The semi-solid residue was treated with n-pentane (2×5 mL) and dried to afford 1-phenyl-piperidin-4-ylamine (0.13 g, 78%) as a solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. additionThe semi-solid residue was treated with n-pentane (2×5 mL)
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6e88ef5f39a64dc4b478bc1f9cd60307
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524705B2

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