反应详情

A solution of 1-phenyl-piperidin-4-one oxime (0.18 g, 0.95 mmol) in methanol (10 mL) was hydrogenated over Raney nickel (0.15 g) under balloon pressure at ambient temperature for 6 h. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo. The semi-solid residue was treated with n-pentane (2×5 mL) and dried to afford 1-phenyl-piperidin-4-ylamine (0.13 g, 78%) as a solid.

1. filtrationThe reaction mixture was filtered through Celite
2. concentrationthe filtrate was concentrated in vacuo
3. additionThe semi-solid residue was treated with n-pentane (2×5 mL)
4. customdried