反应详情

A solution of 2,6-dichloro-4-methyl-pyridine (250 mg, 1.5 mmol) in methanol (2 mL) was added to a solution of sodium methoxide (prepared from sodium (71 mg, 3.0 mmol) and anhydrous methanol (20 mL)) and heated at reflux for 48 h. The solvent was evaporated and the residue partitioned between water and dichloromethane. The organic layer was separated, washed with water, brine, dried over anhydrous sodium sulfate and concentrated to afford 2-chloro-6-methoxy-4-methyl-pyridine (150 mg, 61%) as a pale orange oily liquid.

1. temperatureheated
2. temperatureat reflux for 48 h
3. customThe solvent was evaporated
4. customthe residue partitioned between water and dichloromethane
5. customThe organic layer was separated
6. washwashed with water, brine
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated