HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonate → 1'-[4-(2-chloro-5-trifluoromethylbenzoyl)-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | 3H-spiro[2-benzofuran-1,4'-piperidine] | HCID 10442498 | — |
| Reactant | 4-(2-Chloro-5-trifluoromethylbenzoyl)-1-butanol | HCID 22012164 | — |
| Product | 1'-[4-(2-chloro-5-trifluoromethylbenzoyl)-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine] | HCID 22012217 | — |
Reaction Steps
4-(2-Chloro-5-trifluoromethylbenzoyl)-1-butanol, prepared as described in EXAMPLE 17, was converted to the corresponding methanesulfonate by the method described in EXAMPLE 2. Treatment with spiro[isobenzofuran-1(3H),4'-piperidine] according to the method described in EXAMPLE 2 gave 1'-[4-(2-chloro-5-trifluoromethylbenzoyl)-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine]. Conversion to the corresponding hydrazone and ring closure according to the method described in EXAMPLE 17 gave the title compound, 18, mp: 146-47° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06031099 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-5464a6d395c04792828a26c8b6dfa6e8 |
| Source note | uspto-grants-2000_02 |