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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 378551Generated: October 31, 2026

Potassium Carbonate → HCID 22012231, compound

https://huagongshe.com/reaction/378551

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
ReactantEthyl 3-bromopropionateHCID 68320—
Reactant4-(4-Fluorophenyl)piperidineHCID 2759136—
SolventMethyl Isobutyl KetoneHCID 7909—
ProductHCID 22012231HCID 22012231111.2%

Reaction Steps

A mixture of 4-(4-fluorophenyl)-piperidine (15 g), ethyl 3-bromopropionate (20 g), and potassium carbonate (14 g) in methyl isobutyl ketone was refluxed for 16 h. Filtration and removal of solvent in vacuo gave 26 g of crude ethyl 3-(4-(4-fluorophenyl)-1-piperidyl)propionate as an oil which was used directly in the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06031099
Source datasetuspto-grants-2000_02
ORD IDord-24c2e1a1ef304b3dad14580e41059689
Source noteuspto-grants-2000_02