4-Chlorobenzoyl chloride → 2-[3-(Imidazol-1-yl)propylamino]-2,2-dimethylethyl 4-chlorobenzoate dihydrochloride

HRID 378625Notes

Reaction equation

HRID 378625 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12])[CH:5]=[CH:4][N:3]=[CH:2]1.[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1>>[ClH:15].[ClH:15].[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([O:12][CH2:11][C:10]([NH:9][CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)([CH3:14])[CH3:13])=[O:21])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 183497652-[3-(Imidazol-1-yl)propylamino]-2-methyl-1-propanol

Product 1

HCID 702142942-[3-(Imidazol-1-yl)propylamino]-2,2-dimethylethyl 4-chlorobenzoate dihydrochloride

Procedure

In a similar manner to Example 78, 2-[3-(imidazol-1-yl)propylamino]-2-methyl-1-propanol (1.0 g) was reacted with 4-chlorobenzoyl chloride (0.89 g) to give 2-[3-(imidazol-1-yl)propylamino]-2,2-dimethylethyl 4-chlorobenzoate dihydrochloride, m.p. 207-209° C.

Sources & evidence

ORD record
ord-6c08383be4ed4086bbb39958a762acd9
Source dataset
uspto-grants-2000_02
Patent number
US06031109

Reaction notes

Loading…