HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 378628Generated: October 30, 2026
1,4-Dioxane → N-[1-(4-chlorophenyl)-1-methylethyl]-3-(4-formylimidazol-1-yl)propionamide
https://huagongshe.com/reaction/378628
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| Reactant | 1H-Imidazole-4-carbaldehyde | HCID 76428 | — |
| Reactant | N-[1-(4-chlorophenyl)-1-methylethyl]-acrylamide | HCID 18349731 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[1-(4-chlorophenyl)-1-methylethyl]-3-(4-formylimidazol-1-yl)propionamide | HCID 18349775 | — |
Reaction Steps
A mixture of N-[1-(4-chlorophenyl)-1-methylethyl]acrylamide (22.35 g), imidazole-4-carboxaldehyde (9.6 g), benzyltrimethylammonium hydroxide (2.24 ml of a 40% solution in methanol, Triton®B) and 1,4-dioxane (112 ml) was stirred and heated at 95° C. for 6 hours and then worked up as described in Example 19a to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(4-formylimidazol-1-yl)propionamide, m.p. 151-153° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06031109 |
|---|
| Source dataset | uspto-grants-2000_02 |
|---|
| ORD ID | ord-f43197656e7a40d5ba5216fac9ff1a08 |
|---|
| Source note | uspto-grants-2000_02 |
|---|
