反应详情

A suspension of 4-cyanophenylacetic acid (31.2 g, prepared as described in J.C.S. 744, (1941)), concentrated sulphuric acid (5 ml) and absolute ethanol (300 ml) was boiled under reflux with stirring for 48 hours. The solvent was removed under reduced pressure and dilute aqueous sodium hydroxide solution was added to neutralise the sulphuric acid. Dichloromethane was added. The mixture was filtered and extracted with further dichloromethane. The organic extracts were dried and evaporated to give ethyl 4-cyanophenylacetate, m.p. 94-95° C.

1. temperatureunder reflux
2. customThe solvent was removed under reduced pressure and dilute aqueous sodium hydroxide solution
3. additionwas added
4. additionDichloromethane was added
5. filtrationThe mixture was filtered
6. extractionextracted with further dichloromethane
7. customThe organic extracts were dried
8. customevaporated