反应详情

Sulfuric acid (1 mL) was slowly added to a solution of (2-methoxy-6-nitro-phenyl)-acetonitrile (200 mg, 1.04 mmol) in 95% ethanol (2 mL). The mixture was heated at reflux overnight then quenched into ice cold water and extracted with diethyl ether (10 mL). The organic phase was washed with water (2×10 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to afford (2-methoxy-6-nitro-phenyl)-acetic acid ethyl ester (180 mg, 72%).

1. temperatureThe mixture was heated
2. temperatureat reflux overnight
3. customthen quenched into ice cold water
4. extractionextracted with diethyl ether (10 mL)
5. washThe organic phase was washed with water (2×10 mL)
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated in vacuo