Potassium Hydroxide → HCID 22013005, compound

HRID 378723Notes

Reaction equation

HRID 378723 reaction equation
[CH2:1]([O:3][CH:4]([O:41][CH2:42][CH3:43])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([CH2:26][C:27]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]([O:38]C)=[O:37])=[CH:32][CH:31]=2)=[O:28])([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)=[O:17])[C:7]1=[O:40])[CH3:2].[OH-].[K+]>CO>[CH2:1]([O:3][CH:4]([O:41][CH2:42][CH3:43])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([CH2:26][C:27]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]([OH:38])=[O:37])=[CH:32][CH:31]=2)=[O:28])([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)=[O:17])[C:7]1=[O:40])[CH3:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 22013063HCID 22013063, compound

Product 1

HCID 22013005HCID 22013005, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(RS)-1-(2,2-diethoxyethyl)-3-((4-methoxycarbonylphenyl)aminocarbonylmethyl)-3-(N'-(4-methylphenyl)ureido)indolin-2-one in 30 ml of methanol was added 5 ml of an aqueous solution of 0.20 g of potassium hydroxide (85%) at room temperature. The mixture was stirred for 1 day, followed by concentration.

Workup

  1. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-311a0d47a7d943eb8fd7313459c5814c
Source dataset
uspto-grants-2000_02
Patent number
US06031111

Reaction notes

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