反应详情

A slurry of 1-(4,6-dimethyl-pyridin-2-yl)-4-(4-nitro-phenyl)-piperazine (27 g, 86.5 mmol) in methanol (1 L) was hydrogenated over Raney nickel (8 g) at 70-75 psi and room temperature in a Parr hydrogenation apparatus until no starting material was observed on TLC. The mixture was filtered through Celite and the filtrate concentrated in vacuo to afford 4-[4-(4,6-dimethyl-pyridin-2-yl)-piperazin-1-yl]-phenyl amine (22.2 g, 91%) as a solid which needed no further purification and was used as such in the next step.

1. filtrationThe mixture was filtered through Celite
2. concentrationthe filtrate concentrated in vacuo