HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 4-Amino-3,5,6-trifluoro-2-cyanopyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3,4,5,6-Tetrafluoropyridine-2-carbonitrile | HCID 22463468 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Amino-3,5,6-trifluoro-2-cyanopyridine | HCID 22677407 | 92% |
Reaction Steps
To a solution of 3,4,5,6-tetrafluoro-2-cyanopyridine in DMF (75 mL) at 0C was slowly added concentrated ammonium hydroxide (15 mL). The reaction was stirred and additional 15 min and the solution was diluted with water (150 mL). The solid was collected and air dried to give 4-amino-3,5,6-trifluoro-2-cyanopyridine (25.5 g, 0.16 mol, 92%); mp 291-30 C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297197B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-863ffce9f2b545329952788ae4bad168 |
| Source note | uspto-grants-2001_10 |