Hydrochloric Acid → HCID 12394529, compound

Participants

Reaction Steps

To a solution of 3-bromo-4-chloropyridine-2-carboxylic acid (1.75 g, 7.4 mmol) in MeOH was added anhydrous HCl. The resulting mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated to give a solid, which was partitioned between Et2O and saturated NaHCO3. Organic layer was dried over MgSO4, filtered and concentrated to give a brown residue. This material was purified via flash column chromatography to yield 1.35 g of product as a pale yellow oil.

Provenance & Evidence