Sodium Hydroxide → HCID 21696635, compound

Participants

Reaction Steps

To Methyl 4-amino-3-chloro-6-(3,5-dichlorophenoxy)pyridine-2-carboxylic acid (0.0.720 g, 2.07 mmol) in 20 mL of methanol was added 1N NaOH (2.07 mL) and stirred at RT for 1 hr. The reaction mixture was concentrated to dryness in vacuo and 100 mL each of diethyl ether and H2O added. The aqueous layer acidified with 1N HCl until pH=2. Methylene chloride was added and the aqueous phase was extracted with additional CH2Cl2 (2×100 mL). The combined extracts were dried (MgSO4) and concentrated to dryness in vacuo to give 0.390 g of white solid 4-amino-3-chloro-6-(3,5-dichlorophenoxy)pyridine-2-carboxylic acid (Compound 47); mp 196° C.

Provenance & Evidence