Hydroxyamine hydrochloride → HCID 11143212, compound

Participants

Reaction Steps

To a solution of 3-cyclopropyl-2-(bis(methylthio)methylene)-1-(2-chloro-4-methylsulfonylphenyl)propan-1,3-dione (123 mg, 0.304 mmol) in ethanol (15 mL) was added hydroxylamine hydrochloride (23 mg, 0.334 mmol) and sodium acetate (25 mg, 0.304 mmol). The resulting mixture was stirred at r.t. overnight, then evaporated to dryness and the residue was taken up in ethyl acetate, washed with water, dried and evaporated to dryness. The crude product was purified by preparative Thin-layer chromatography to give 90 mg of crystalline 5-cyclopropyl-3-methylthio-4-(2-chloro-4-methylsulfonylbenzoyl)isoxazole, m.p. 141° C.

Provenance & Evidence