1-Methylhomopiperazine → 5-Methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole

HRID 378883Notes

Reaction equation

HRID 378883 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:12][N:13]1[CH2:19][CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:16]3[CH2:17][CH2:18][CH2:19][N:13]([CH3:12])[CH2:14][CH2:15]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 178423563HCID 178423563, compound

Product 1

HCID 225582075-Methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5-Methyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylhomopiperazine (1.24 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1) to obtain the title compound 5-methyl-2-(4-methyl-1-homopiperazinyl) benzoxazole (124 mg).

Workup

  1. temperaturewith heating for 2 days
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1)

Sources & evidence

ORD record
ord-c088900aef634085860a9144b4f7a6c6
Source dataset
uspto-grants-2001_10
Patent number
US06297246B1

Reaction notes

Loading…