1-Methylhomopiperazine → HCID 22558211, compound

HRID 378887Notes

Reaction equation

HRID 378887 reaction equation
[Cl:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:13][N:14]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]2[O:9][C:8]([N:17]3[CH2:18][CH2:19][CH2:20][N:14]([CH3:13])[CH2:15][CH2:16]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 178422392HCID 178422392, compound

Product 1

HCID 22558211HCID 22558211, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5-Chloro-6-methyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylhomopiperazine (1.24 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5-chloro-6-methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole (183 mg).

Workup

  1. temperaturewith heating for 2 days
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)

Sources & evidence

ORD record
ord-58a18320c95949fcbaff1f67abd776e8
Source dataset
uspto-grants-2001_10
Patent number
US06297246B1

Reaction notes

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