1-Methylhomopiperazine → HCID 22558199, compound

HRID 378888Notes

Reaction equation

HRID 378888 reaction equation
S[C:2]1[O:3][C:4]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:5]=2[N:6]=1.[CH3:15][N:16]1[CH2:22][CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(Cl)(Cl)Cl>[CH3:15][N:16]1[CH2:22][CH2:21][CH2:20][N:19]([C:2]2[O:3][C:4]3[CH:14]=[CH:13][C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[C:5]=3[N:6]=2)[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 178527765HCID 178527765, compound

Product 1

HCID 22558199HCID 22558199, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-Mercapto-naphtho[1,2-d]oxazole (200 mg) was dissolved in chloroform (20 ml), N-methylhomopiperazine (2.48 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1) to obtain the title compound 2-(4-methyl-1-homopiperazinyl)naphtho[1,2-d]oxazole (137 mg).

Workup

  1. temperaturewith heating for 2 days
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=10:1)

Sources & evidence

ORD record
ord-d99b7ac7099b4123a9e7fd0c4ffcd070
Source dataset
uspto-grants-2001_10
Patent number
US06297246B1

Reaction notes

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