1,2,3,4-Tetrahydroisoquinoline → HCID 11784505, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,4,6,8-tetrachloropyrimidopyrimidine (0.54 g, 8.0 mmol) in THF (50 ml) was added a solution of 1,2,3,4-tetrahydroisoquinoline (1.0 ml) in THF (15 ml) dropwise over 10 minutes. The mixture was stirred for 12 hours at 25° C., the resultant solid was removed by filtration. The filtrate was evaporated under reduced pressure to afford a brown solid. Chromatography on silica gel, employing petrol:EtOAc (8:2) as eluent, afforded the title compound as a pale brown powder (0.27 g, 7%).

Provenance & Evidence