HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 378947Generated: October 25, 2026
Sodium Hydroxide → 2-Amino-4-(3,5-diacetylphenyl)imino-1,4-dihydro-1,6-dimethylpyrimidine
https://huagongshe.com/reaction/378947
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Amino-4-(3,5-diacetylphenyl)amino-1,6-dimethylpyrimidinium iodide | HCID 9845352 | — |
| Reactant | Methanol--water (1/1) | HCID 22242641 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Amino-4-(3,5-diacetylphenyl)imino-1,4-dihydro-1,6-dimethylpyrimidine | HCID 73089 | 99.9% |
Reaction Steps
A suspension of 21 g (49.3 mmole) of 2-amino-4-(3,5-diacetylphenyl)amino-1,6-dimethylpyrimidinium iodide (compound No. 2, synthesized as described in section 6.1) in 1:1 methanol/water (750 mL) at 60° C. was treated with excess 2N NaOH with cooling to maintain about 60° C. An additional 200 mL of water was added and the mixture was cooled in ice and filtered to give 14.69 g 2-amino-4-(3,5-diacetylphenyl)imino-1,4-dihydro-1,6-dimethylpyrimidine as yellow crystals, mp 219-220°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06297253B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-41cd9cab2caf4f86ac754778a7ae4165 |
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| Source note | uspto-grants-2001_10 |
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