Ethanol → 4-Ethoxycarbonylphenylboronic acid

HRID 378962Notes

Reaction equation

HRID 378962 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([B:10]([OH:12])[OH:11])=[CH:6][CH:5]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[CH2:18]([O:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([B:10]([OH:12])[OH:11])=[CH:8][CH:9]=1)=[O:3])[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3121834-Carboxyphenylboronic Acid

Product 1

HCID 27343504-Ethoxycarbonylphenylboronic acid

Procedure

A solution of 4-carboxyphenylboronic acid (1 5 g, 0.09 mol), 99% ethanol (150 mL) and concentrated sulphuric acid (0.5 mL) was heated to reflux for two days. The volume was reduced to approximately 20 mL. The residue was triturated with petroleum ether to give 13.4 g of the desired material.

Workup

  1. temperatureto reflux for two days
  2. customThe residue was triturated with petroleum ether

Sources & evidence

ORD record
ord-4157f65b0a9c4f688caf8c36d44738be
Source dataset
uspto-grants-2001_10
Patent number
US06297261B1

Reaction notes

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