HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[2-(2-cyclopentyloxy-3-methoxy-phenyl)-ethyl]-2-pyridin-4-yl-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(2-Cyclopentyloxy-3-methoxy-phenyl)-ethylamine Hydrochloride | HCID 21697267 | — |
| Reactant | HCID 57455229 | HCID 57455229 | — |
| Solvent | Chloride | HCID 312 | — |
| Product | N-[2-(2-cyclopentyloxy-3-methoxy-phenyl)-ethyl]-2-pyridin-4-yl-acetamide | HCID 21697280 | 108.9% |
Reaction Steps
Operating analogously to example 46 using 2-(2-cyclopentyloxy-3-methoxy-phenyl)-ethylamine hydrochloride (1 g, 3.68 mmoles), obtained as described in example 3, in methliene chloride (20 ml), triethylamine (1.69 ml, 1.23 g, 12.14 mmoles) and isonicotinic acid hydrochloride (0.72 g, 4.05 mmoles), 1.42 g of the title product were obtained (yield: 99.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297257B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-41f80ffdfcb5458bb01cf4be5535787a |
| Source note | uspto-grants-2001_10 |