反应详情

378 mg of ethoxycarbonylmethyl 5-{[2-(3-benzyl-ureido)-thiazole-4-carbonyl]-amino}-2-ethoxycarbonylmethoxy-benzoate, 6.5 ml of ethanol and 1.29 ml of 2N sodium hydroxide solution are stirred for 5 hrs. at RT. After the addition of 3 ml of acetic acid and 2 ml of water the mixture is warmed until a homogeneous solution is obtained. After cooling the precipitate is filtered off under suction, washed with acetic acid-water 1:1 and dried. There are obtained 290 mg of 5-{[2-(3-benzyl-ureido)-thiazole-4-carbonyl]-amino}-2-carboxymethoxy-benzoic acid, m.p. 219° C., MS: 471 (M+H)+.

1. customat RT
2. temperatureis warmed until a homogeneous solution
3. customis obtained
4. temperatureAfter cooling the precipitate
5. filtrationis filtered off under suction
6. washwashed with acetic acid-water 1:1
7. customdried