HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 3-Cyclopentyloxy-4-methoxybenzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Hydroxy-4-methoxybenzyl alcohol | HCID 78089 | — |
| Reactant | Cyclopentyloxy-bromide | HCID 21697665 | — |
| Product | 3-Cyclopentyloxy-4-methoxybenzyl alcohol | HCID 11138706 | 35.8% |
Reaction Steps
From 3-hydroxy-4-methoxybenzyl alcohol (50 g, 0.324 mol), cyclopentyloxybromide (70 ml, 0.648 mol), caesium carbonate (72.83 g, 0.222 mol) and sodium iodide (5.63 g, 0.037 mol). Chromatography (SiO2; EtOAc—C6H14. 1:3) to yield the title compound (25.782 g). (Found C, 69.92; H, 8.18. C13H18O3 requires C, 70.25; H, 8.16).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297264B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-e6fa687aa13d40f5a9e8e9c0c5092204 |
| Source note | uspto-grants-2001_10 |