Hydrochloric Acid → HCID 21697092, compound

Participants

Reaction Conditions

Reaction Steps

A solution of phenyl 2-hydroxy-4-iodobenzoate, as described in Example 1, Step A, (2.38 g, 7.0 mmol) and Zn(CN)2 (575 mg, 4.9 mmol) in DMF was degassed with argon for 25 minutes. Pd(Ph3P)4 (404 mg, 0.35 mmol) was added and the mixture heated to 80° C. for 16 hr. The mixture was poured into 1N HCl and extracted with EtOAc (2×), washed with water then brine, dried (MgSO4) and the solvent removed. Chromatography of the residue (silica gel; hexane:EtOAc 9:1) afforded the title compound as a white solid.

Provenance & Evidence