Phenol → HCID 21697025, compound

Participants

Reaction Steps

To a solution of a phenol, as described in Step A, in 5 mL of dimethyl formamide (DMF) was added biphenyl-4-ylethyl iodide (170 mg, 0.55 mmol) and Cs2CO3 (246 mg, 0.75 mmol). The suspension was stirred for 16 hr. After this time, the reaction mixture was diluted with EtOAc, extracted with water (3×), washed with brine, dried (MgSO4) and concentrated in vacuo. The residue was purified by flash chromatography (SiO2; hexane:EtOAc 9:1 then 4:1) to provide the title compound.

Provenance & Evidence