Hydrochloric Acid → Benzoic acid, 4-amino-3-hydroxy-, methyl ester

Participants

Reaction Conditions

Reaction Steps

HCl (g) was bubbled through a solution of 4-amino-3-hydroxybenzoic acid (7 g, 54.8 mmol) in MeOH (450 mL) until saturated then the mixture was heated at 70° C. for 16 hr. The mixture was concentrated in vacuo, the residue taken up in EtOAc, washed with saturated NaHCO3 then brine and dried (MgSO4). Removal of the solvent yielded the title compound as a brown solid.

Provenance & Evidence