HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 4-(Bromomethyl)-2-hydroxybenzonitrile | HCID 21696993 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile | HCID 21697028 | — |
Reaction Steps
4-Bromomethyl-2-hydroxy-benzonitrile (0.22 g, 1.05 mmol) and imidazole (0.36 g, 5.23 mmol) were dissolved in DMF (10 mL) with stirring at ambient temperature. After stirring for 18 h the reaction mixture was concentrated in vacuo and purified by silica gel chromatography eluting with 2% CH3OH/CH2Cl2 to 5% CH3OH/CH2Cl2 to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297239B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-fd218a04b3084973923057e2d5ebd771 |
| Source note | uspto-grants-2001_10 |