Dimethyl Sulfide → [4-Iodo-3-(naphthalen-2-yloxy)-phenyl]-methyl bromide

Participants

Reaction Steps

To a solution of [4-iodo-3-(naphthalen-2-yloxy)-phenyl]-methanol (0.085 g, 0.226 mmol) in CH2Cl2 (2 mL) at −15° C. was added a cold (0° C.) solution of N-bromosuccinimide (0.120 g, 0.68 mmol) in dimethyl sulfide (0.060 mL, 0.814 mmol) with stirring. The reaction mixture was allowed to warm to ambient temperature overnight, concentrated to dryness, and chromatographed (SiO2, 10% EtOAc:hexane) to give the title compound which was used without purification.

Provenance & Evidence