Acetic Acid → HCID 21697022, compound

Participants

Reaction Steps

To a solution of 2-(3-chloro-phenoxy)-4-[(4-chloro-phenyl)-imidazol-1-yl-methyl]-benzonitrile trifluoroacetate (0.065 g, 0.122 mmol) in acetonitrile (5 mL) was added 1M KOH (0.5 mL) (pH=9-10) and 37% aqueous formaldehyde (0.14 mL) After stirring for 18 hr the mixture was adjusted to pH=3 with acetic acid, diluted with CH3OH (3 mL) and purified on prep HPLC. The TFA salt was converted to the HCl salt to obtain the title compound.

Provenance & Evidence