HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 2-Fluoro-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 2-Fluoro-4-(hydroxy(1-methyl-1h-imidazol-5-yl)methyl)benzonitrile | HCID 18533201 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Fluoro-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile | HCID 18533205 | — |
Reaction Steps
2-Fluoro-4-[hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile (as described in Example 22, Step E) (0.655 g, 2.83 mmol) and MnO2 (1.23 g, 14.2 mmol) were stirred in CH2Cl2 (50 mL) and CH3CN (5 mL) for 72 h. The solution was filtered and concentrated to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297239B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-19d2e1097f044f92a6d58bf07bdeb4a2 |
| Source note | uspto-grants-2001_10 |