Hydrochloric Acid → N5-(iminomethoxymethyl)-L-ornithine dihydrochloride

Participants

Reaction Conditions

Reaction Steps

A solution of 0.75 g (1.96 mmol) N2-(tert-butoxycarbonyl)-N5-(iminomethoxymethyl)-L-ornithine tert-butyl ester hydrochloride in 2 mL dioxane at 0° C. was treated with 15 mL of 4N hydrochloric acid in dioxane solution. The solution was stirred overnight at 22° C., concentrated to a crude paste, and freeze-dried from 8 mL of water. The product was freeze-dried a second time to yield 0.53 g N5-(iminomethoxymethyl)-L-ornithine dihydrochloride. The product analyzed solvated with an additional 0.2 molar hydrochloric acid 0.1 molar water, and 0.3 molar dioxane.

Provenance & Evidence