Benzoyl chloride → HCID 57559154, compound

HRID 37915Notes

Reaction equation

HRID 37915 reaction equation
[CH2:1]1[C:14]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[NH:7][C:6]=2[C:5]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])=[CH:4][NH:3][CH2:2]1.[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:21]([N:3]1[CH2:2][CH2:1][C:14]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[NH:7][C:6]=2[C:5]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])=[CH:4]1)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 25223167HCID 25223167, compound

Product 1

HCID 57559154HCID 57559154, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using iso-propyl 1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate (Example 3) and benzoyl chloride; 1H-NMR (CDCl3): δ 10.48 (1H, br s), 7.98 (1H, s), 7.47 (2H, m), 7.41 (2H, m), 7.40 (2H, m), 7.30 (1H, m), 7.15 (1H, m), 6.99 (1H, m), 5.04 (1H, m), 4.15 (2H, t), 3.2 (2H, d), 1.10 (6H, d); MS (ES): 375 (MH+).

Sources & evidence

ORD record
ord-d9c3f4c2de5442359cc28d672288d8cd
Source dataset
uspto-grants-2013_09
Patent number
US08524704B2

Reaction notes

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