Bis(2-Methoxyethyl)amine → 4-[Bis-(2-methoxy-ethyl)-amino]-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide

Participants

Role	Name	HCID	Charge
Reactant	Bis(2-Methoxyethyl)amine	HCID 2383	—
Reactant	4-Bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide	HCID 54242075	—
Product	4-[Bis-(2-methoxy-ethyl)-amino]-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide	HCID 67202953	—

Reaction Steps

In the mamner of Example 103, 4-bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide and bis-(2-methoxy-ethyl)-amine was converted to 52.3 mg of the title compound as the bis-trifluoroacetate salt mass spectrum (electrospray, m/e): M+H 542.0.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06297258B1
Source dataset	uspto-grants-2001_10
ORD ID	ord-a4d2f8fa194e4eb6aec26830ff085868
Source note	uspto-grants-2001_10