HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4,7-Trioxa-10-azacyclododecane → HCID 72997908, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4,7-Trioxa-10-azacyclododecane | HCID 545817 | — |
| Reactant | 4-Bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide | HCID 54242075 | — |
| Product | HCID 72997908 | HCID 72997908 | — |
Reaction Steps
In the mamner of Example 103, 4-bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide and 1,4,7-trioxa-10-aza cyclododecane was converted to 37.5 mg of the title compound(free base) and mass spectrum (electrospray, m/e): M+H 584.1, 17.1 mg of the title compound as the bis-trifluoroacetate salt); mass spectrum (electrospray, m/e): M+H 584.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297258B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-007bfb5c350d40ca82f64798a7ecf765 |
| Source note | uspto-grants-2001_10 |